Fractional dosing of vaccines

A research report by Witold Więcek

Fractional dosing of vaccines

What if a different vaccine dose or schedule could protect more people?

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An investigation into evidence, implementation, and the limits of optimisation.
Draft · June 2024

Evidence and mechanisms Case studies Research priorities

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Where to begin

01 / Overview

Why change the dose?

Biology, development, delivery, and population benefit.

 02 / Vaccines

Where might it matter?

Short assessments across infectious diseases.

 03 / Case studies

What has been tried?

COVID, mpox, polio, and yellow fever.

 04 / Research agenda

What should we test?

Possible projects, gaps, and reasons for scepticism.

The central question

A fixed supply need not mean a fixed number of people protected.

Dose, timing, and delivery affect individual immune responses and the reach of a vaccination programme. Finding better regimens requires biological evidence, practical feasibility, and decisions that weigh population benefits against uncertainty.